We combined the two workhorses in gene expression from the beginning of the twenty-first century — microarrays and next-generation sequencing — to create Array-seq, a simple, large-format platform for spatial transcriptomics. Array-seq is (i) scalable thanks to its large format (11.31 cm²) and low cost, (ii) easy to adopt without special expertise or instrumentation, (iii) compatible with H&E staining—the gold standard for clinical pathology diagnosis—and (iv) readily applicable to all fields of basic and clinical research.

Original publication: Cipurko et al., Nature Methods, 2025.